研究

郭晶晶 Guo Jingjing

客座教授

教授，博士生導師，2015年博士畢業於蘭州大學藥物化學專業，在蛋白質結構與功能、生物膜對有機小分子響應等方面取得了一系列創新性成果，目前發表SCI論文40餘篇，包括Chemical Reviews、Elife等國際權威期刊。

學習經歷：
2009-2015 蘭州大學大學，博士
2013-2015 美國佛羅里達州立大學，聯合培養博士
2005-2009 河北師範大學，學士

工作經歷：
2022-至今澳門理工大學，客座教授
2019-2022 南京農業大學，教授
2017-2018 新加坡南洋理工大學，Research Fellow
2015-2017 河南師範大學，副教授

以計算生物學爲主要研究特色，圍繞蛋白質和生物膜的結構與功能、功能分子設計等開展工作。具體研究方向包括：

Guo, J.; Zhou, H.-X., Protein allostery and conformational dynamics. Chem. Rev. 2016, 116 (11), 6503-15.

GPCRs:

M. Li; Y. Bao; M. Li; J. Guo*, GPCR Allostery: a View from Computational Biology. Current Medicinal Chemistry, 2023, Accept
Li, M.; Li, M.; Guo, J.*, Molecular Mechanism of Ca(2+) in the Allosteric Regulation of Human Parathyroid Hormone Receptor-1. J. Chem. Inf. Model. 2022, 62, 5110.
M. Li; Y. Bao; R. Xu; M. Li; L. Xi; J. Guo*, Understanding the Allosteric Modulation of PTH1R by a Negative Allosteric Modulator. Cells, 2023, 12, 41.
M. Li; Y. Bao; R. Xu; X. Zhang; H. La; J. Guo*, Mechanism of enhanced sensitivity of mutated beta-adrenergic-like octopamine receptor to amitraz in honeybee Apis mellifera: An insight from MD simulations. Pest Manag Sci, 2022, 78, 5423.

Enzymes:

Zhong, W.^#; Guo, J. ^#; Cui, L.^#; Chionh, Y. H.; Li, K.; El Sahili, A.; Cai, Q.; Yuan, M.; Michels, P. A. M.; Fothergill-Gilmore, L. A.; Walkinshaw, M. D.; Mu, Y.; Lescar, J.; Dedon, P. C., Pyruvate kinase regulates the pentose-phosphate pathway in response to hypoxia in Mycobacterium tuberculosis. J. Mol. Biol. 2019, 431 (19), 3690-3705. (Co-first author)
Guo, J.; Zhou, H. X., Allosteric activation of SENP1 by SUMO1 beta-grasp domain involves a dock-and-coalesce mechanism. Elife 2016, 5, e18249.
Guo, J.; Pang, X.; Zhou, H.-X., Two pathways mediate interdomain allosteric regulation in pin1. Structure 2015, 23 (1), 237-47.

P. Xin*; L. Xu; W. Dong; L. Mao; J. Guo*; J. Bi; S. Zhang; Y. Pei; C. P. Chen*, Synthetic K⁺ Channels Constructed by Rebuilding the Core Modules of Natural K+ Channels in an Artificial System. Angew Chem Int Ed Engl, 2023. https://doi.org/10.1002/anie.202217859
Bao, Y.; Li, M.; Xie, Y.; Guo, J.*, Investigating the Permeation Mechanism of Typical Phthalic Acid Esters (PAEs) and Membrane Response Using Molecular Dynamics Simulations. Membranes 2022, 12 (6), 596.
Guo, J.; Chia, G. W. N.; Berezhnoy, N. V.; Cazenave-Gassiot, A.; Kjelleberg, S.; Hinks, J.; Mu, Y.; Seviour, T., Bacterial lipopolysaccharide core structures mediate effects of butanol ingress. BBA-Biomembranes 2020, 1862 (2), 183150.
Guo, J.; Ho, J. C. S.; Chin, H.; Mark, A. E.; Zhou, C.; Kjelleberg, S.; Liedberg, B.; Parikh, A. N.; Cho, N. J.; Hinks, J.; Mu, Y.; Seviour, T., Response of microbial membranes to butanol: interdigitation vs. disorder. Phys. Chem. Chem. Phys. 2019, 21 (22), 11903-11915.