2016/2017
Sex differences in release of cardiac troponin T after endurance exercise
Biomarkers, 2016, 22(3-4):345-350
| 作者 | Zhaowei Kong/
Jinlei Nie/
Hua Lin/
Keith George/
Gang Zhao/
Haifeng Zhang/
Tomas K. Tong/
Qingde Shi |
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| 摘要 |
CONTEXT:
Post-exercise cardiac troponin release has been extensively described in athletic groups but little attention has been given to any role of sex in mediating this phenomenon.
OBJECTIVE:
We compared the release of cardiac troponin T (cTnT) after endurance running in training-experience, biological-age and maturity-matched young male and female runners.
MATERIALS AND METHODS:
Nineteen male (training history: 2.3 ± 1.0 years; mean age: 16.1 ± 1.2 years; Tanner stage: 3.7 ± 0.6) and 19 female (training history: 2.2 ± 1.0 years; mean age: 15.9 ± 1.4 years; Tanner stage: 4.0 ± 0.4) runners performed a 21 km run with "all-out" effort. Serum cTnT levels were assessed at pre-exercise (Pre-ex) and at 4 h post-exercise (Post-ex).
RESULTS:
At Pre-ex, cTnT concentrations were below the 99th percentile value (10 ng.l-1) in 32/38 runners. Post-ex cTnT increased in all subjects but the response was substantially higher (p < 0.05) in males [median (range): 210 (20-1360) ng.l-1] than females [median (range): 80 (10-550) ng.l-1]. At Post-ex, 95% (95% confidence interval: 75-99%) of males and 63% (95% confidence interval: 41-81%) of females (p < 0.05) had cTnT concentrations above the cut-off for acute myocardial infarction.
CONCLUSIONS:
The present data suggest that post-exercise cTnT elevation occurs in all runners but is augmented in young male compared to female athletes.
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