2018/2019
Cardiac biomarker release after exercise in healthy children and adolescents: A systematic review and meta-analysis^
Pediatric Exercise Science*, 2019, 31(1):28-36
Author(s) | Cirer-Sastre R, Legaz-Arrese A, Corbi F, George K, Nie J, Carranza-Garcia LE, Reverter-Masià J |
---|---|
Summary | Purpose: The authors evaluated the impact of acute exercise and 24-hour recovery on serum concentration of cardiac troponins T and I (cTnT and cTnI) and N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP) in healthy children and adolescents. The authors also determined the proportion of participants exceeding the upper reference limits and acute myocardial infarction cutoff for each assay.
Method: Web of Science, SPORTDiscus, MEDLINE, ScienceDirect, and Scopus databases were systematically searched up to November 2017. Studies were screened and quality-assessed; the data was systematically extracted and analyzed.
Results: From 751 studies initially identified, 14 met the inclusion criteria for data extraction. All 3 biomarkers were increased significantly after exercise. A decrease from postexercise to 24 hours was noted in cTnT and cTnI, although this decrease was only statistically significant for cTnT. The upper reference limit was exceeded by 76% of participants for cTnT, a 51% for cTnI, and a 13% for NT-proBNP. Furthermore, the cutoff value for acute myocardial infarction was exceeded by 39% for cTnT and a 11% for cTnI. Postexercise peak values of cTnT were associated with duration and intensity (Q (3) = 28.3, P < .001) while NT-proBNP peak values were associated with duration (Q (2) = 11.9, P = .003).
Conclusion: Exercise results in the appearance of elevated levels of cTnT, cTnI, and NT-proBNP in children and adolescents. Postexercise elevations of cTnT and NT-proBNP are associated with exercise duration and intensity. |
* It is also listed in SCI/SCIE
^ 同時列入不同索引的文章