Informação Geral

Objectives:

We aimed to further explore the relationship between blood lipid and Pulse Wave Velocity (PWV).

Methods:

We retrospectively selected subjects who had ever been treated in the outpatient or inpatient clinic. The subjects included were sub-grouped into Group A (no history of hypertension and dyslipidemia), Group B (with a history of dyslipidemia but not hypertension), Group C (with a history of hypertension but not dyslipidemia) and Group D (with a history of hypertension and dyslipidemia). We determine brachial-ankle Pulse Wave Velocity (baPWV), atherogenic index of plasma (AIP), non-high density lipoprotein (non-HDL-C), total cholesterol/HDL-C and atherogenic index (AI) between hypertension/non-hypertension and dyslipidemia/non-dyslipidemia patients.

Results:

354 subjects were included. Uric acid, systolic pressure, diastolic pressure, pulse pressure and mean arterial pressure differed among the groups with statistical significance. The prevalence of coronary arterial disease and diabetes mellitus, age, body mass index, heart rate, blood glucose, creatinine, urea, history of smoking and drinking did not differ among the groups. BaPWV differed in both hypertension/non-hypertension and dyslipidemia/non- dyslipidemia patients with statistical significance. In hypertension patients (Groups C, D), TC, AI, AIP, TC/HDL, and non-HDL-C were correlated to ΔbaPWV but not HDL-C, LDL-C and TG. In hypertension patients (Group C, D), partial correlation analysis showed that baPWV was also correlated to systolic pressure, diastolic pressure, mean arterial pressure, age, urea and heart rate.

Conclusion:

TC, AIP, AI, non-HDL-C and TC/HDL-C might be correlated to arterial stiffness and their pathological raising may be risk factors for arterial stiffness. However, this requires further investigation.